Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
Microbiol Mol Biol Rev. 2013 Mar;77(1):73-111. doi: 10.1128/MMBR.00046-12.
Cell-cell communication, or quorum sensing, is a widespread phenomenon in bacteria that is used to coordinate gene expression among local populations. Its use by bacterial pathogens to regulate genes that promote invasion, defense, and spread has been particularly well documented. With the ongoing emergence of antibiotic-resistant pathogens, there is a current need for development of alternative therapeutic strategies. An antivirulence approach by which quorum sensing is impeded has caught on as a viable means to manipulate bacterial processes, especially pathogenic traits that are harmful to human and animal health and agricultural productivity. The identification and development of chemical compounds and enzymes that facilitate quorum-sensing inhibition (QSI) by targeting signaling molecules, signal biogenesis, or signal detection are reviewed here. Overall, the evidence suggests that QSI therapy may be efficacious against some, but not necessarily all, bacterial pathogens, and several failures and ongoing concerns that may steer future studies in productive directions are discussed. Nevertheless, various QSI successes have rightfully perpetuated excitement surrounding new potential therapies, and this review highlights promising QSI leads in disrupting pathogenesis in both plants and animals.
细胞间通讯，或群体感应，是细菌中广泛存在的一种现象，用于协调局部群体中的基因表达。细菌病原体利用它来调节促进入侵、防御和传播的基因已经得到了很好的记录。随着抗生素耐药性病原体的不断出现，目前需要开发替代治疗策略。一种通过干扰群体感应来抑制细菌活力的抗病毒方法已经成为一种可行的手段，可以操纵细菌的过程，特别是对人类和动物健康以及农业生产力有害的致病性特征。本文综述了识别和开发化学化合物和酶的进展，这些化合物和酶通过靶向信号分子、信号生物发生或信号检测来促进群体感应抑制（QSI）。总的来说，有证据表明，QSI 疗法可能对一些但不是所有的细菌病原体有效，并且讨论了几个失败和正在出现的问题，这些问题可能会引导未来的研究朝着富有成效的方向发展。尽管如此，各种 QSI 的成功确实激发了人们对新的潜在治疗方法的兴奋，并且本综述强调了在破坏动植物发病机制方面有前途的 QSI 先导化合物。
