Komi P V, Viitasalo J H, Havu M, Thorstensson A, Sjödin B, Karlsson J
Acta Physiol Scand. 1977 Aug;100(4):385-92. doi: 10.1111/j.1365-201X.1977.tb00001.x.
Significance of the genetic component in determining the interindividual variation observed in skeletal muscle fibre composition and enzyme activities was investigated in 31 pairs of male and female monozygous (MZ) and dizygous (DZ) twins, whose ages ranged in all but one pair (11 years) from 15 to 24 years. Percent distribution of slow twitch muscle fibres and activities of Ca2+ and Ng2+ stimulated ATPases, creatine phosphokinase, myokinase, phosphorylase, lactate dehydrogenase (LDH) and distribution of its isozyme LDH-1 were all analyzed in biopsy samples taken from the vastus lateralis muscle. The data disclosed that in contrast to DZ twins the MZ twins of both sexes had an essentially identical muscle fibre composition. Calculation of the heritability estimate for this parameter gave the values of 99.5% and 92.8%, respectively for males and females. In contrast to the fibre composition presence of a significant genetic component was not observed in any of the enzyme activities studied. It was concluded that there is a predominant genetic influence on the skeletal muscle fibre composition in man, and thus also on the potential capacity of the muscles to perform work.
在31对年龄在15至24岁之间（只有一对为11岁）的男性和女性同卵（MZ）及异卵（DZ）双胞胎中，研究了遗传成分在决定骨骼肌纤维组成和酶活性个体间差异方面的意义。从股外侧肌采集活检样本，分析慢肌纤维的百分比分布以及Ca2+和Mg2+刺激的ATP酶、肌酸磷酸激酶、肌激酶、磷酸化酶、乳酸脱氢酶（LDH）的活性及其同工酶LDH-1的分布。数据显示，与异卵双胞胎不同，同卵双胞胎无论男女，其肌肉纤维组成基本相同。对该参数的遗传力估计计算得出，男性和女性的遗传力值分别为99.5%和92.8%。与纤维组成不同，在所研究的任何酶活性中均未观察到显著的遗传成分。研究得出结论，人类骨骼肌纤维组成存在主要的遗传影响，因此对肌肉做功的潜在能力也有主要遗传影响。
