Department of Medicine, The Children's Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Indian J Pediatr. 2009 Sep;76(9):959-62. doi: 10.1007/s12098-009-0194-y. Epub 2009 Nov 4.
To investigate the clinical features of Kikuchi-Fujimoto disease (KFD) and the relationship between viral infection and this disease in children will be better as Kikuchi-Fujimoto disease (KFD) is a lymphadenopathy. The aim of study is to investigate the clinical features of KFD and the relationship. The age, gender, clinical features and aetiopathogenesis of 36 Chinese children with FKD were reviewed, and the viral antigens were detected. Mean age was 10.1 +/- 2.8 yr with a male to female ratio of 1.8:1. Fever and lymphadenopathy were the most common complaints, noted in 23 and all cases respectively. Skin rash and hepatosplenomegaly were also noted. Leukopenia, anemia, thrombocytopenia and raised ESR were noted in 21, 6, 4 and 31 cases respectively. Epstein-Barr virus (EBV) IgM and IgG was positive in 1 and 24 of 29 cases respectively. Antigens of EBV and herpes simplex virus 2 (HSV 2) were found in the biopsy tissue section from 2 and 1 case respectively. Autoantibodies were noted in 3 of 15 cases. Steroid hormones were administrated for 19 cases with good efficacy. These results imply that children with lymphadenopathy and/or fever may have KFD and thus excisional biopsy of lymph nodes should be performed earlier on. A hyperimmune reaction of immune cells to EBV and HSV2 may play a role in the pathology of KFD.
为了研究儿童奇克氏病（KFD）的临床特征以及病毒感染与该病的关系，奇克氏病（KFD）是一种淋巴结病。本研究旨在探讨 KFD 的临床特征及其关系。回顾性分析了 36 例中国儿童 FKD 的年龄、性别、临床特征和病因，检测了病毒抗原。平均年龄为 10.1 +/- 2.8 岁，男女比例为 1.8:1。发热和淋巴结肿大是最常见的症状，分别在 23 例和所有病例中出现。皮疹和肝脾肿大也有报道。21 例有白细胞减少症，6 例有贫血，4 例有血小板减少，31 例有血沉升高。EBV IgM 和 IgG 在 29 例中的阳性率分别为 1 和 24。在 2 例和 1 例活检组织切片中发现 EBV 和单纯疱疹病毒 2（HSV 2）的抗原。在 15 例中有 3 例有自身抗体。19 例患者给予激素治疗，疗效良好。这些结果表明，有淋巴结病和/或发热的儿童可能患有 KFD，因此应更早地进行淋巴结切除活检。免疫细胞对 EBV 和 HSV2 的超免疫反应可能在 KFD 的病理中起作用。
