Department of Occupational Safety and Health, College of Public Health, China Medical University, Taichung, Taiwan.
J Occup Environ Hyg. 2010 Jan;7(1):14-22. doi: 10.1080/15459620903344652.
Independent exposure to noise, N,N-dimethylformamide (DMF), or toluene has been associated with cardiovascular effects, but the combined effects are not clear. This study investigated ambulatory systolic blood pressure (SBP) and diastolic blood pressure (DBP) in workers co-exposed to noise, DMF, and toluene. Twenty workers in a synthetic leather manufacturing company were recruited as study subjects. Personal noise exposure and ambulatory blood pressure were measured concomitantly for 24 hr; airborne co-exposure to DMF and toluene during the working period was also analyzed to identify solvents exposure. Linear mixed-effects regressions were used to estimate effects on ambulatory blood pressure by controlling potential confounders. Four high-combined-exposure workers (83 +/- 8 dBA; DMF: 3.23 +/- 2.15 ppm, toluene: 1.09 +/- 1.13 ppm) had the higher means of 16 +/- 7 mmHg in 24-hr DBP (p = 0.027) and 21 +/- 8 mmHg in working-time DBP (p = 0.048) than seven low-combined-exposure workers (73 +/- 12 dBA; DMF: 0.41 +/- 0.02 ppm, toluene: 0.12 +/- 0.01 ppm). Three high-noise-exposure workers (84 +/- 7 dBA) also had a marginal increase of 13 +/- 6 mmHg in DBP at work (p = 0.076) compared with the control group. No significant differences in SBP and DBP were found between six high-solvent-exposure workers (DMF: 1.24 +/- 1.25 ppm, toluene: 2.63 +/- 1.29 ppm) and office workers during any periods. After the Bonferroni correction, there were no significant differences in ambulatory blood pressure between three high-exposure groups and the low-exposure groups. Our findings suggest no interactive effects of co-exposure to noise, DMF, and toluene on workers' ambulatory blood pressure.
独立接触噪声、N,N-二甲基甲酰胺（DMF）或甲苯与心血管效应有关，但联合接触的影响尚不清楚。本研究调查了同时接触噪声、DMF 和甲苯的工人的动态收缩压（SBP）和舒张压（DBP）。从一家合成革制造公司招募了 20 名工人作为研究对象。同时测量了 24 小时内的个人噪声暴露和动态血压；还分析了工作期间空气中 DMF 和甲苯的共暴露情况，以确定溶剂暴露。使用线性混合效应回归来控制潜在混杂因素，估计对动态血压的影响。四名高综合暴露工人（83 +/- 8 dBA；DMF：3.23 +/- 2.15 ppm，甲苯：1.09 +/- 1.13 ppm）的 24 小时 DBP 平均值较高，为 16 +/- 7 mmHg（p = 0.027），工作时间 DBP 平均值较高，为 21 +/- 8 mmHg（p = 0.048），而七名低综合暴露工人（73 +/- 12 dBA；DMF：0.41 +/- 0.02 ppm，甲苯：0.12 +/- 0.01 ppm）。三名高噪声暴露工人（84 +/- 7 dBA）在工作时 DBP 也有 13 +/- 6 mmHg 的轻度增加（p = 0.076），与对照组相比。在任何时间段，六名高溶剂暴露工人（DMF：1.24 +/- 1.25 ppm，甲苯：2.63 +/- 1.29 ppm）和办公室工作人员之间的 SBP 和 DBP 均无显著差异。经 Bonferroni 校正后，三组高暴露组与低暴露组之间的动态血压无显著差异。我们的发现表明，噪声、DMF 和甲苯的共暴露对工人的动态血压没有交互影响。
