Beko K R, Tran H O, Hewitt C W, Black K S, Patel M P, Ramsamooj R, Martin D C
Department of Surgery, University of California, Irvine 92717.
Transplant Proc. 1991 Feb;23(1 Pt 1):147-8.
Skin allografts were not enhanced by prior conditioning of blood and CyA (5 or 10 mg/kg/d). However, when BM-CyA pretreatment was used, SA survival was significantly prolonged (CyA, 5 or 10 mg/kg/d). In examining differences between the BT-CyA and BM-CyA protocols, equivocal levels of donor microchimerism (1.5%) were found in the spleens of BT-CyA conditioned recipients at the time of transplantation (day 0). In contrast, highly significant levels of splenic donor chimerism (17.2%) developed at day 0 for the BM-CyA pretransplant recipients. Skin-allograft prolongation under the BM-CyA protocol implied that the effect may be linked to the existence of a donor-specific stem-cell population in the recipient animal.
血液预先处理及使用环孢素A（5或10毫克/千克/天）并未增强皮肤同种异体移植效果。然而，当采用骨髓-环孢素A预处理时，皮肤同种异体移植存活时间显著延长（环孢素A，5或10毫克/千克/天）。在研究骨髓移植-环孢素A方案与血液输注-环孢素A方案之间的差异时，在移植时（第0天）发现血液输注-环孢素A预处理受体的脾脏中存在模糊水平的供体微嵌合体（1.5%）。相比之下，骨髓移植-环孢素A预处理受体在第0天脾脏中出现了高度显著水平的供体嵌合体（17.2%）。骨髓移植-环孢素A方案下皮肤同种异体移植存活时间的延长表明，这种效应可能与受体动物中供体特异性干细胞群的存在有关。
