为了全合成 Goniodomin A，一种作用于肌动蛋白的海洋聚醚大环内酯：C15-C36 片段的汇聚合成。
Toward the total synthesis of goniodomin A, an actin-targeting marine polyether macrolide: convergent synthesis of the C15-C36 segment.
机构信息
Graduate School of Life Sciences, Tohoku University, 1-1 Tsutsumidori-amamiya, Aoba-ku, Sendai 981-8555, Japan.
出版信息
Org Lett. 2009 Nov 19;11(22):5274-7. doi: 10.1021/ol902217q.
PMID:19905029
Abstract
Stereoselective convergent synthesis of the C15-C36 segment of goniodomin A, an actin-targeting marine polyether macrolide natural product, has been achieved. The present synthesis features palladium(0)-catalyzed, copper(I)-mediated Liebeskind-Srogl cross-coupling as the fragment assembly process.
摘要
岗田酸 C15-C36 片段的立体选择性汇聚合成，一种作用于肌动蛋白的海洋聚醚大环内酯天然产物，已经完成。本合成采用钯(0)催化、铜(I)介导的 Liebeskind-Srogl 交叉偶联作为片段组装过程。
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