通过钯催化的有机锡-硫酯偶联反应实现 Goniodomin A 的 C1-C16 片段的会聚合成。
A convergent synthesis of the C1-C16 segment of goniodomin A via palladium-catalyzed organostannane-thioester coupling.
机构信息
Laboratory of Biostructural Chemistry, Graduate School of Life Sciences, Tohoku University, Aoba-ku, Sendai, Japan.
出版信息
Org Lett. 2011 Mar 4;13(5):1106-9. doi: 10.1021/ol1031409. Epub 2011 Feb 10.
PMID:21309568
Abstract
A convergent synthesis of the C1-C16 segment of goniodomin A, an actin-targeting marine polyether macrolide natural product, has been achieved via a 2-fold application of palladium-catalyzed organostannane-thioester coupling.
摘要
通过钯催化的有机锡-硫酯偶联的 2 倍应用，实现了 Goniodomin A（一种作用于肌动蛋白的海洋聚醚大环内酯天然产物）的 C1-C16 片段的汇聚合成。
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