Enhos Sukru, Duran Ismet, Erdem Sami, Buyukbas Sadik
Private Practice, Kayseri, Turkey.
J Periodontol. 2009 Nov;80(11):1750-5. doi: 10.1902/jop.2009.090209.
The aim of this study was to evaluate the periodontal status of patients with iron-deficiency anemia (IDA) and the correlation of changes in serum and gingival crevicular fluid (GCF) ferritin levels after periodontal therapy.
Nineteen female patients with anemic hematologic values were classified as group A, and 20 healthy females with normal hematologic values were classified as group B. After group A was recruited, group B was enrolled with patients who had similar gingival indices as group A. At baseline and the 3-month follow-up visit, clinical periodontal indices and hematologic parameters were recorded, and GCF samples were taken. All patients received an oral hygiene-improvement session followed by scaling, and sites with >4-mm probing depths received root planing. At the 3-month follow-up visit, all measurements and analyses were repeated.
During the follow-up period, all clinical indices decreased in both groups (P <0.05), but the gingival index in group A did not change. The GCF ferritin concentration showed statistically significant decreases (P <0.05), but total amounts of ferritin in GCF did not change. No significant correlation was found between serum and GCF ferritin levels.
The findings of this study showed that changes in serum ferritin levels did not correlate with the GCF ferritin levels, and IDA was not a direct risk factor for periodontal diseases.
本研究旨在评估缺铁性贫血（IDA）患者的牙周状况，以及牙周治疗后血清和龈沟液（GCF）铁蛋白水平变化的相关性。
将19名血液学指标贫血的女性患者分为A组，20名血液学指标正常的健康女性分为B组。招募A组患者后，纳入与A组牙龈指数相似的患者作为B组。在基线和3个月随访时，记录临床牙周指标和血液学参数，并采集GCF样本。所有患者均接受口腔卫生改善治疗，随后进行龈上洁治，探诊深度>4 mm的部位进行根面平整。在3个月随访时，重复所有测量和分析。
随访期间，两组所有临床指标均下降（P<0.05），但A组牙龈指数未变化。GCF铁蛋白浓度有统计学意义的下降（P<0.05），但GCF中铁蛋白总量未变化。血清和GCF铁蛋白水平之间未发现显著相关性。
本研究结果表明，血清铁蛋白水平的变化与GCF铁蛋白水平无关，IDA不是牙周疾病的直接危险因素。
