Vogelsang Petra, Hovden Arnt-Ove, Jonsson Roland, Appel Silke
Broegelmann Research Laboratory, The Gade Institute, University of Bergen, Bergen, Norway.
Scand J Immunol. 2009 Dec;70(6):541-6. doi: 10.1111/j.1365-3083.2009.02327.x.
Dendritic cells (DC) are a heterogeneous group of professional antigen-presenting cells (APC) involved in both initiating immune responses and maintaining tolerance. Roughly, DC can be divided into plasmacytoid DC (pDC) and conventional DC (cDC). By controlling regulatory T cells (Treg), DC can influence the outcome of both immunity and autoimmunity. Since the use of mice as in vivo models became a practical tool for researchers studying pathological events in all kind of human diseases, we decided to compare levels of cDC, pDC and Treg in both spleen and blood between two inbred mouse strains. Here we show that two commonly used mouse strains, BALB/c and C57BL/10J mice, have significantly different levels of distinct CD11c(+)/CD4(-)/CD8a(+), CD11c(+)/CD4(+)/CD8a(-) and CD11c(+)/CD4(-)/CD8a(-) cDC populations, pDC and Treg. Therefore, we emphasize the importance of considering the proper model when comparing data sets from different mouse strains.
树突状细胞（DC）是一类异质性的专职抗原呈递细胞（APC），参与启动免疫反应和维持免疫耐受。大致来说，DC可分为浆细胞样DC（pDC）和常规DC（cDC）。通过控制调节性T细胞（Treg），DC可以影响免疫和自身免疫的结果。自从将小鼠用作体内模型成为研究各类人类疾病病理事件的研究人员的实用工具以来，我们决定比较两种近交系小鼠品系脾脏和血液中cDC、pDC和Treg的水平。在此我们表明，两种常用的小鼠品系BALB/c和C57BL/10J小鼠，其不同的CD11c(+)/CD4(-)/CD8a(+)、CD11c(+)/CD4(+)/CD8a(-)和CD11c(+)/CD4(-)/CD8a(-) cDC亚群、pDC和Treg水平存在显著差异。因此，我们强调在比较来自不同小鼠品系的数据集时考虑合适模型的重要性。
