Department of Cell Biology and Human Anatomy, University of California, School of Medicine, Davis, California, USA.
Nutr Rev. 2009 Nov;67 Suppl 2:S172-82. doi: 10.1111/j.1753-4887.2009.00238.x.
A healthy mucosal immune system prevents numerous diseases whether they are caused by pathogens or faulty tolerance to non-pathogenic antigens. Some methods for assessing immune responses have not changed for decades but have been applied in conjunction with new strategies. New methods have been developed recently that improve on existing mouse models and allow for assessment of cellular and molecular pathways that are involved in mucosal immune responses. Reviewed here are components of the mucosal immune system with attention paid to the gut-associated lymphoid tissue and some of the new methods for assessing immune responses.
健康的黏膜免疫系统可以预防许多疾病，无论这些疾病是由病原体引起的，还是由对非致病性抗原的错误耐受引起的。一些评估免疫反应的方法几十年来没有改变，但与新策略结合使用。最近开发了一些新方法，改进了现有的小鼠模型，并能够评估参与黏膜免疫反应的细胞和分子途径。本文综述了黏膜免疫系统的组成部分，重点介绍了肠道相关淋巴组织和一些新的免疫反应评估方法。
