Mylonakis M E, Day M J, Siarkou V, Vernau W, Koutinas A F
Companion Animal Clinic, Faculty of Veterinary Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.
J Comp Pathol. 2010 May;142(4):328-31. doi: 10.1016/j.jcpa.2009.09.003. Epub 2009 Nov 10.
Bone marrow (BM) pathology was assessed in 10 dogs with Ehrlichia canis-induced aplastic pancytopenia. BM core biopsy sections were stained with haematoxylin and eosin and with haematoxylin/van Gieson and Gordon and Sweets' reticulin stain for the detection of collagen and reticulin fibres, respectively. Iron stores were assessed by Perls' Prussian blue staining. There was no significant deposition of collagen or reticulin in any sample, but in seven dogs the BM was depleted of haemosiderin. These findings suggest that myelofibrosis does not play a significant role in the development of BM failure in canine monocytic ehrlichiosis and that iron deficiency may exacerbate the anaemia in the myelosuppressive phase of the disease.
对10只患有犬埃立希体引起的再生障碍性全血细胞减少症的犬进行了骨髓（BM）病理学评估。骨髓芯活检切片分别用苏木精和伊红、苏木精/范吉森以及戈登和斯威茨网状纤维染色，以检测胶原纤维和网状纤维。通过佩尔斯普鲁士蓝染色评估铁储存情况。在任何样本中均未发现胶原或网状纤维有明显沉积，但在7只犬中，骨髓中的含铁血黄素减少。这些发现表明，骨髓纤维化在犬单核细胞埃立希体病骨髓衰竭的发展中不起重要作用，并且缺铁可能会加重该疾病骨髓抑制期的贫血。
