用于纳米技术应用的独立 DNA 寡核苷酸组。

Independent sets of DNA oligonucleotides for nanotechnology applications.

机构信息

Department of Computer Science and Computer Engineering, University of Arkansas, Fayetteville, AR 72701, USA.

出版信息

IEEE Trans Nanobioscience. 2010 Mar;9(1):38-43. doi: 10.1109/TNB.2009.2035446. Epub 2009 Nov 10.

DOI:10.1109/TNB.2009.2035446

PMID:19906601

Abstract

Independent sets of DNA oligonucleotides, which only bind with their Watson-Crick complements, have potential use in self-assembly of nanostructures, since they minimize errors and inefficiency from unwanted binding. A software tool implemented a thermodynamic model for DNA duplex formation and was used to generate large independent sets of DNA oligonucleotides. The principle of the approach was experimentally verified on a sample set of oligonucleotides.

摘要

独立的 DNA 寡核苷酸序列仅与其 Watson-Crick 互补序列结合，因此在自组装纳米结构方面具有潜在的应用，因为它们可以最大程度地减少由于不需要的结合而导致的错误和效率低下。一个软件工具实现了 DNA 双链体形成的热力学模型，并用于生成大量的独立 DNA 寡核苷酸序列。该方法的原理在一组寡核苷酸样品上进行了实验验证。