Hirasawa K, Enosawa S
Immunobiology Group, Meiji Institute of Health Science, Odawara, Japan.
Transplant Proc. 1991 Feb;23(1 Pt 1):714-5.
Adult male recipients could accept allogeneic skin graft with CyA treatment alone for considerably long periods, whereas young male and female, and adult females were not susceptible to the immunosuppression. When testosterone or prednisolone was administered with CyA as a combination therapy to young male and adult female recipients, the survival time of the graft was significantly prolonged. On the contrary, estradiol totally inhibited the immunosuppressive activity of CyA in any recipients. These present data strongly suggested that immunoreactivity against transplantation antigens can be influenced by sex steroid hormones, and that the usage of steroid combination therapy may overcome the lack of immunosuppression by CyA induced by the female sex steroid estradiol.
成年男性受体单独使用环孢素（CyA）治疗时可在相当长的时间内接受同种异体皮肤移植，而年轻男性和女性以及成年女性对这种免疫抑制不敏感。当睾酮或泼尼松龙与环孢素联合使用作为联合疗法用于年轻男性和成年女性受体时，移植物的存活时间显著延长。相反，雌二醇在任何受体中都完全抑制了环孢素的免疫抑制活性。这些现有数据有力地表明，针对移植抗原的免疫反应性可能受性类固醇激素影响，并且类固醇联合疗法的使用可能克服由女性性类固醇雌二醇诱导的环孢素免疫抑制不足的问题。
