Ragon Institute of MGH, MIT, and Harvard, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.
J Virol. 2010 Feb;84(3):1656-63. doi: 10.1128/JVI.01499-09. Epub 2009 Nov 11.
Hepatitis C virus (HCV)-specific CD8(+) T cells in persistent HCV infection are low in frequency and paradoxically show a phenotype associated with controlled infections, expressing the memory marker CD127. We addressed to what extent this phenotype is dependent on the presence of cognate antigen. We analyzed virus-specific responses in acute and chronic HCV infections and sequenced autologous virus. We show that CD127 expression is associated with decreased antigenic stimulation after either viral clearance or viral variation. Our data indicate that most CD8 T-cell responses in chronic HCV infection do not target the circulating virus and that the appearance of HCV-specific CD127(+) T cells is driven by viral variation.
慢性丙型肝炎病毒（HCV）感染患者体内 HCV 特异性 CD8(+) T 细胞频率较低，且这些细胞表现出与控制感染相关的表型，表达记忆标志物 CD127。我们研究了这种表型在多大程度上依赖于同源抗原的存在。我们分析了急性和慢性 HCV 感染中的病毒特异性反应，并对自体病毒进行了测序。结果表明，病毒清除或变异后，CD127 的表达与抗原刺激减少有关。我们的数据表明，慢性 HCV 感染中的大多数 CD8 T 细胞反应并非针对循环病毒，而 HCV 特异性 CD127(+) T 细胞的出现是由病毒变异驱动的。
