Klinik für Immunologie und Rheumatologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
J Virol. 2010 Jan;84(2):1183-8. doi: 10.1128/JVI.01675-09. Epub 2009 Nov 11.
HIV-1 infection is characterized by loss of CD56(dim) CD16(+) NK cells and increased terminal differentiation on various lymphocyte subsets. We identified a decrease of CD57(-) and CD57(dim) cells but not of CD57(bright) cells on CD56(dim) CD16(+) NK cells in chronic HIV infection. Increasing CD57 expression was strongly associated with increasing frequencies of killer immunoglobulin-like receptors (KIRs) and granzyme B-expressing cells but decreasing percentages of cells expressing CD27(+), HLA-DR(+), Ki-67(+), and CD107a. Our data indicate that HIV leads to a decline of less-differentiated cells and suggest that CD57 is a useful marker for terminal differentiation on NK cells.
HIV-1 感染的特征是 CD56(dim) CD16(+) NK 细胞的丧失和各种淋巴细胞亚群上的终末分化增加。我们发现慢性 HIV 感染中 CD56(dim) CD16(+) NK 细胞上的 CD57(-)和 CD57(dim)细胞减少，但 CD57(bright)细胞没有减少。CD57 表达的增加与杀伤免疫球蛋白样受体 (KIR) 和表达颗粒酶 B 的细胞频率的增加密切相关，但与表达 CD27(+)、HLA-DR(+)、Ki-67(+)和 CD107a 的细胞百分比的减少相关。我们的数据表明，HIV 导致分化程度较低的细胞减少，并表明 CD57 是 NK 细胞终末分化的有用标志物。
