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CCR7 在 CD56(bright)NK 细胞上的表达缺失与 CD56(dim)CD16⁺ NK 样表型相关，并与 HIV 病毒载量相关。

Loss of CCR7 expression on CD56(bright) NK cells is associated with a CD56(dim)CD16⁺ NK cell-like phenotype and correlates with HIV viral load.

机构信息

Klinik für Immunologie und Rheumatologie, Medizinische Hochschule Hannover, Hannover, Germany.

出版信息

PLoS One. 2012;7(9):e44820. doi: 10.1371/journal.pone.0044820. Epub 2012 Sep 19.

DOI:10.1371/journal.pone.0044820
PMID:23028633
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3447005/
Abstract

NK cells are pivotal sentinels of the innate immune system and distinct subpopulations in peripheral blood have been described. A number of studies addressed HIV-induced alterations of NK cell phenotype and functionality mainly focusing on CD56(dim)CD16⁺ and CD56⁻CD16⁺ NK cells. However, the impact of HIV-infection on CD56(bright) NK cells is less well understood. Here we report a rise of CD56(bright) NK cells in HIV-infected individuals, which lack CCR7-expression and strongly correlate with HIV viral load. CCR7⁻CD56(bright) NK cells were characterized by increased cytolytic potential, higher activation states and a more differentiated phenotype. These cells thus acquired a number of features of CD56(dim)CD16⁺ NK cells. Furthermore, CD56(bright) NK cells from HIV patients exhibited higher degranulation levels compared to uninfected individuals. Thus, chronic HIV-infection is associated with a phenotypic and functional shift of CD56(bright) NK cells, which provides a novel aspect of HIV-associated pathogenesis within the NK cell compartment.

摘要

自然杀伤 (NK) 细胞是先天免疫系统的关键哨兵，在外周血中已经描述了不同的亚群。许多研究都针对 HIV 诱导的 NK 细胞表型和功能改变，主要集中在 CD56(dim)CD16⁺ 和 CD56⁻CD16⁺ NK 细胞上。然而，HIV 感染对 CD56(bright) NK 细胞的影响了解较少。在这里，我们报告了 HIV 感染个体中 CD56(bright) NK 细胞的增加，这些细胞缺乏 CCR7 表达，与 HIV 病毒载量强烈相关。CCR7⁻CD56(bright) NK 细胞具有增强的细胞毒性潜力、更高的激活状态和更分化的表型。因此，这些细胞获得了 CD56(dim)CD16⁺ NK 细胞的许多特征。此外，与未感染个体相比，HIV 患者的 CD56(bright) NK 细胞脱颗粒水平更高。因此，慢性 HIV 感染与 CD56(bright) NK 细胞的表型和功能转变有关，这为 NK 细胞中与 HIV 相关的发病机制提供了一个新的方面。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bc7/3447005/41018ed82ee6/pone.0044820.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bc7/3447005/f0d288a310e8/pone.0044820.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bc7/3447005/b25e5dbcbcb2/pone.0044820.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bc7/3447005/e51794bd439d/pone.0044820.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bc7/3447005/41018ed82ee6/pone.0044820.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bc7/3447005/f0d288a310e8/pone.0044820.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bc7/3447005/b25e5dbcbcb2/pone.0044820.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bc7/3447005/e51794bd439d/pone.0044820.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bc7/3447005/41018ed82ee6/pone.0044820.g004.jpg

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