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Calcium and diabetic vascular dysfunction. Focus on "Elevated Ca(2+) sparklet activity during acute hyperglycemia and diabetes in cerebral arterial smooth muscle cells".

作者信息

Dunn Kathryn M, Nelson Mark T

出版信息

Am J Physiol Cell Physiol. 2010 Feb;298(2):C203-5. doi: 10.1152/ajpcell.00499.2009. Epub 2009 Nov 11.

DOI:10.1152/ajpcell.00499.2009
PMID:19907015
Abstract
摘要

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引用本文的文献

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Salidroside contributes to reducing blood pressure and alleviating cerebrovascular contractile activity in diabetic Goto-Kakizaki Rats by inhibition of L-type calcium channel in smooth muscle cells.红景天苷通过抑制平滑肌细胞中的L型钙通道，有助于降低糖尿病Goto-Kakizaki大鼠的血压并减轻脑血管收缩活动。
BMC Pharmacol Toxicol. 2017 Apr 26;18(1):30. doi: 10.1186/s40360-017-0135-8.
2
Berberine alleviates the cerebrovascular contractility in streptozotocin-induced diabetic rats through modulation of intracellular Ca²⁺ handling in smooth muscle cells.黄连素通过调节平滑肌细胞内钙离子的处理来减轻链脲佐菌素诱导的糖尿病大鼠的脑血管收缩性。
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Distinct and complementary roles for α and β isoenzymes of PKC in mediating vasoconstrictor responses to acutely elevated glucose.
蛋白激酶C的α和β同工酶在介导对急性血糖升高的血管收缩反应中具有不同且互补的作用。
Br J Pharmacol. 2016 Mar;173(5):870-87. doi: 10.1111/bph.13399. Epub 2016 Feb 8.
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Regulation of large conductance Ca2+-activated K+ (BK) channel β1 subunit expression by muscle RING finger protein 1 in diabetic vessels.肌肉环指蛋白 1 调节糖尿病血管中大电导钙激活钾（BK）通道 β1 亚基的表达。
J Biol Chem. 2014 Apr 11;289(15):10853-10864. doi: 10.1074/jbc.M113.520940. Epub 2014 Feb 25.
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Intracellular Ca2+ regulating proteins in vascular smooth muscle cells are altered with type 1 diabetes due to the direct effects of hyperglycemia.由于高血糖的直接作用，1 型糖尿病会改变血管平滑肌细胞中的细胞内 Ca2+调节蛋白。
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