铁调素在铁代谢中的作用。
The role of hepcidin in iron metabolism.
作者信息
Nemeth Elizabeta, Ganz Tomas
机构信息
David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA.
出版信息
Acta Haematol. 2009;122(2-3):78-86. doi: 10.1159/000243791. Epub 2009 Nov 10.
Abstract
Hepcidin is the central regulator of systemic iron homeostasis. Dysregulation of hepcidin production results in a variety of iron disorders. Hepcidin deficiency is the cause of iron overload in hereditary hemochromatosis, iron-loading anemias, and hepatitis C. Hepcidin excess is associated with anemia of inflammation, chronic kidney disease and iron-refractory iron deficiency anemia. Diagnostic and therapeutic applications of this new knowledge are beginning to emerge. Dr. Ernest Beutler played a significant role in advancing our understanding of the function of hepcidin. This review is dedicated to his memory.
摘要
铁调素是全身铁稳态的核心调节因子。铁调素产生的失调会导致多种铁紊乱。铁调素缺乏是遗传性血色素沉着症、铁过载性贫血和丙型肝炎中铁过载的原因。铁调素过量与炎症性贫血、慢性肾病和铁难治性缺铁性贫血有关。这一新知识的诊断和治疗应用已开始出现。欧内斯特·博伊特勒博士在推动我们对铁调素功能的理解方面发挥了重要作用。本综述谨以此纪念他。
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