Extracorporeal Multiorgan Support Dialysis Excellent Center, Chulalongkorn University, Bangkok, Thailand.
Blood Purif. 2010;29(1):35-43. doi: 10.1159/000255955. Epub 2009 Nov 7.
A recent cross-sectional study demonstrated that convective-controlled double high-flux hemodiafiltration (CC-HDF) could yield equivalent removal of small and middle molecule uremic toxins to on-line hemodiafiltration (OL-HDF).
The present study was conducted to compare the 1-year efficacy between CC-HDF (n = 10) and OL-HDF (n = 16) in chronic hemodialysis patients undergoing thrice weekly high-flux hemodialysis for at least 6 months.
When compared with baseline (high-flux hemodialysis), 1-year treatment with both HDF modes had comparable efficacy in significantly lowering serum pre-dialysis beta(2)-microglobulin (beta(2)m) levels (p < 0.05) and significantly enhancing greater urea reduction ratio (p < 0.05). Both HDF modes could comparably maintain the hematology profile, calcium-phosphorus metabolism, and nutritional status according to the K-DOQI guidelines.
CC-HDF can provide equivalent 1-year efficacy to OL-HDF and would be an effective alternative mode to OL-HDF.
最近的一项横断面研究表明，对流控制型高通量血液透析滤过（CC-HDF）在清除中小分子尿毒症毒素方面与在线血液透析滤过（OL-HDF）相当。
本研究旨在比较 CC-HDF（n=10）和 OL-HDF（n=16）在至少接受了 6 个月每周三次高通量血液透析的慢性血液透析患者中，1 年的疗效。
与基线（高通量血液透析）相比，1 年的两种 HDF 模式治疗均能显著降低血清透析前β2-微球蛋白（β2m）水平（p＜0.05），显著提高更大的尿素清除率（p＜0.05）。根据 K-DOQI 指南，两种 HDF 模式均能相当程度地维持血液学特征、钙磷代谢和营养状况。
CC-HDF 可提供与 OL-HDF 相当的 1 年疗效，是 OL-HDF 的有效替代模式。
