Clinical Medicine and Immunological Science Departemnt, Dermatology Section, Le Scotte University Hospital, Siena, Italy.
G Ital Dermatol Venereol. 2009 Dec;144(6):729-34.
A 15-week-old baby girl, born at the 29 week of gestation, presented with a four-week history of demarcated, erythematous, erosive and exudative patches on the perianal, perioral and acral areas. A clinical diagnosis of zinc deficiency was considered. Serum zinc level was decreased (0.5 mg/L; normal 0.70-1.50 mg/L), the mother's serum and milk had normal zinc values. The baby was started an empiric trial of oral zinc supplementation (3 mg zinc gluconate/kg body weight/ day) with complete healing of lesions after two weeks. Treatment was gradually withdrawn at six months of age with no relapse. Transient zinc deficiency due to increased zinc requirements in breast-fed mainly preterm infants is a condition similar to acrodermatitis enteropathica, an autosomal recessive disorder of enteric zinc absorption affecting almost exclusively not breast-fed infants. Early recognition of the disorder and introduction of zinc supplementation rapidly reverses transient zinc deficiency, that probably will become more and more frequent, because of the rising rate of premature infants with breast-feeding only.
一名 15 周大的女婴，胎龄 29 周出生，出现肛周、口周和肢端界限分明的红斑、糜烂和渗出性斑块，病史 4 周。临床考虑锌缺乏症。血清锌水平降低（0.5 毫克/升；正常值 0.70-1.50 毫克/升），母亲的血清和乳汁锌值正常。婴儿开始经验性口服补锌治疗（3 毫克葡萄糖酸锌/千克体重/天），两周后皮损完全愈合。6 个月大时逐渐停药，无复发。主要由母乳喂养的早产儿对锌的需求增加引起的短暂性锌缺乏症是一种类似于肠病性肢端皮炎的情况，肠内锌吸收的常染色体隐性障碍几乎只影响非母乳喂养的婴儿。早期识别这种疾病并补充锌可以迅速逆转短暂性锌缺乏症，这种情况可能会越来越普遍，因为母乳喂养的早产儿数量不断增加。
