环糊精的独特结构与性质及其在透皮给药中的应用
Unique structure and property of cyclodextrins and their application in transdermal drug delivery.
作者信息
Hu J, Tao Z, Cao S
机构信息
School of Materials Science and Engineering, Jiangsu University, Zhenjiang 212013, China.
出版信息
Methods Find Exp Clin Pharmacol. 2009 Sep;31(7):449-56. doi: 10.1358/mf.2009.31.7.1406702.
Owing to their bioadaptability and multifunctional characteristics, cyclodextrins have been shown to be useful in drug delivery systems. This article presents the unique structure and properties and the current application of natural and chemically modified cyclodextrins in transdermal drug delivery systems, focusing on their ability to enhance the solubility and stability of drug molecules and to improve drug absorption across biological barriers.
由于其生物适应性和多功能特性，环糊精已被证明在药物递送系统中很有用。本文介绍了天然和化学修饰的环糊精在透皮给药系统中的独特结构和性质以及当前应用，重点关注它们增强药物分子的溶解度和稳定性以及改善药物跨生物屏障吸收的能力。
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