Negrao Bianca Lee, Crafford Dalene, Viljoen Margaretha
Department of Physiology, School of Medicine, Faculty of Health Sciences, University of Pretoria.
Cardiovasc J Afr. 2009 Sep-Oct;20(5):296-9.
The aim of this study was to investigate the effects of sympathomimetic medication on the cardiovascular system of children with attention-deficit/hyperactivity disorder (ADHD).
Cardiovascular functioning of children with ADHD (n = 19) was tested while the children were stimulant free and during a period in which they were on stimulant medication. Electrocardiograms (ECGs) were obtained by means of a Schiller CardioLaptop AT-110 ECG recorder using the standard 12-lead cable positioning for a resting ECG. Blood pressure was measured by means of a stethoscope and mercury sphygmomanometer.
The main findings of this study were that methylphenidate usage is associated with increases in heart rate (HR) and blood pressure (BP), and that it does not adversely affect HR-corrected QT and JT intervals or cardiac dispersion values.
Methylphenidate causes an increase in HR as well as increases in both systolic and diastolic BP, but no change in cardiac depolarisation and repolarisation duration or homogeneity.
本研究旨在探讨拟交感神经药物对注意力缺陷多动障碍（ADHD）儿童心血管系统的影响。
对19名ADHD儿童在未服用兴奋剂时以及服用兴奋剂期间的心血管功能进行测试。使用席勒CardioLaptop AT - 110心电图记录仪，采用标准12导联电缆定位获取静息心电图。通过听诊器和汞柱血压计测量血压。
本研究的主要发现是，使用哌甲酯与心率（HR）和血压（BP）升高有关，且对心率校正的QT和JT间期或心脏离散值无不良影响。
哌甲酯可导致心率升高以及收缩压和舒张压升高，但心脏去极化和复极化持续时间或同质性无变化。
