[The clinical study of using Pingyangmycin of high concentration to treat vascular malformation in oral and maxillofacial region].

PURPOSE

To evaluate the clinical effect of using high concentration Pingyangmycin to treat vascular malformation in oral and maxillofacial region.

METHODS

One hundred and fourteen patients with venous malformation in oral and maxillofacial region (50 males and 64 females, age range: 12-76 years) were treated in our department from 2002 to 2008. The lesions ranged in size from 2.0cmx1.5cm to 15cmx10cm. Pingyangmycin (about 8mg/3mL) was injected into the center or periphery of the venous malformation, the injection was repeated every 15 to 30 days when necessary, and may be conducted for 1-5 times. Based on clinical data, retrospective analysis was carried out for the patients who had been followed up for 0.5-5 years after the last treatment. The scale of the results was graded to excellent, good, fair, and poor.

RESULTS

The curative rate of subcutaneous venous malformation and mucosal venous malformation was 92% and 96%, respectively.

CONCLUSION

It can be concluded that Pingyangmycin injection at high concentration is safe and effective in the treatment of venous malformation in oral and maxillofacial region.