Zhi Keqian, Wen Yuming, Li Longjiang, Ren Wenhao
Department of Oral and Maxillofacial Surgery, College of Stomatology, Xi'an Jiaotong University, Number 98, Xiwu Road, Xi'an 710004, ShaanXi, China.
Int J Pediatr Otorhinolaryngol. 2008 May;72(5):593-7. doi: 10.1016/j.ijporl.2008.01.007. Epub 2008 Feb 21.
To investigate the effect of intralesional Pingyangmycin injection in venous malformation of facial and maxillary region.
From September 2001 to October 2004, 82 patients were referred with venous malformation for intralesional Pingyangmycin injection.
After a minimum follow-up of 2 years, 67 patients (81.7%) developed 76-100% regression in their lesions; 12 patients (14.6%) had 51-75% regression in their lesion; 3 patients underwent surgical excision for the residual swellings. No changes in renal function or cytopenias were encountered. No patients developed chest X-ray changes during the course of therapy. There were no mortalities.
Intralesional injection of Pingyangmycin is an effective, inexpensive, and safe method in venous malformation of facial and maxillary region. We now favor Pingyangmycin sclerotherapy before considering surgical excision in all cases of venous malformation in our hospital.
探讨平阳霉素瘤内注射治疗面颈部静脉畸形的效果。
2001年9月至2004年10月，82例静脉畸形患者接受平阳霉素瘤内注射治疗。
经过至少2年的随访，67例患者（81.7%）病变消退76% - 100%；12例患者（14.6%）病变消退51% - 75%；3例患者因残余肿胀接受手术切除。未发现肾功能改变或血细胞减少。治疗过程中无患者出现胸部X线改变。无死亡病例。
平阳霉素瘤内注射是治疗面颈部静脉畸形的一种有效、廉价且安全的方法。我院目前在考虑对所有静脉畸形病例进行手术切除之前，更倾向于平阳霉素硬化治疗。
