Discovery Biology, Translational Research Institute, The Scripps Research Institute, Scripps Florida, 130 Scripps Way, Jupiter, FL 33458, USA.
Cell Mol Life Sci. 2010 Jan;67(2):171-7. doi: 10.1007/s00018-009-0189-x. Epub 2009 Nov 12.
The emerging critical implications of Rho/Rho-kinase (ROCK) signaling in neurodegenerative diseases, glaucoma, renoprotection, diabetes and cancer have sparked growing interest in the pharmacological potential of ROCK inhibitors beyond their current application in cardiovascular disease. This article discusses the therapeutic benefits of novel ROCK inhibitors in development, and highlights the recent advances in the current understanding of disease-dependent and isoform-specific functions of ROCK and their potential impact on future therapeutic strategies.
Rho/Rho-kinase（ROCK）信号在神经退行性疾病、青光眼、肾保护、糖尿病和癌症中的新兴关键意义，激发了人们对 ROCK 抑制剂除了在心血管疾病中的现有应用之外的药理学潜力的浓厚兴趣。本文讨论了新型 ROCK 抑制剂在开发中的治疗益处，并强调了 ROCK 的疾病依赖性和同工型特异性功能的最新进展及其对未来治疗策略的潜在影响。
