Amoh Yasuyuki, Hoffman Robert M
AntiCancer, Inc., San Diego, CA, USA.
Methods Mol Biol. 2010;585:401-20. doi: 10.1007/978-1-60761-380-0_28.
The hair follicle is dynamic, cycling between growth (anagen), regression (catagen), and resting (telogen) phases throughout life. We have demonstrated that nestin-expressing hair follicle stem cells give rise to follicle structures during early anagen or growth phase of the hair follicle. Nestin-expressing hair follicle stem cells appear in the hair follicular stem cell area, the permanent upper hair follicle immediately below the sebaceous glands and above the bulge area. The nestin-expressing hair follicle stem cells can differentiate into neurons, glia, keratinocytes, smooth muscle cells, and melanocytes in vitro. Furthermore, the hair follicle stem cells promote the recovery of peripheral nerve and spinal cord injury. We have termed these cells hair follicle pluripotent stem (hfPS) cells. These results suggest that hfPS cells provide an important accessible, autologous source of adult stem cells with potential for use in regenerative medicine.
毛囊是动态的，在整个生命过程中经历生长（生长期）、退化（退行期）和休止（静止期）阶段的循环。我们已经证明，表达巢蛋白的毛囊干细胞在毛囊早期生长期或生长阶段产生毛囊结构。表达巢蛋白的毛囊干细胞出现在毛囊干细胞区域，即皮脂腺下方和隆突区域上方的永久性上半毛囊。表达巢蛋白的毛囊干细胞在体外可分化为神经元、神经胶质细胞、角质形成细胞、平滑肌细胞和黑素细胞。此外，毛囊干细胞可促进周围神经和脊髓损伤的恢复。我们将这些细胞称为毛囊多能干细胞（hfPS细胞）。这些结果表明，hfPS细胞提供了一种重要的、可获取的成体干细胞自体来源，具有在再生医学中应用的潜力。
