Department of Dermatology, Kitasato University School of Medicine, Kanagawa, Japan.
J Dermatol. 2012 Jan;39(1):33-8. doi: 10.1111/j.1346-8138.2011.01413.x. Epub 2011 Nov 21.
Nestin-positive, keratin 15 (K15)-negative multipotent hair follicle stem cells are located above the hair follicle bulge. We have termed this location the hair follicle pluripotent stem cell area. We have previously shown that transplantation of nestin-expressing hair follicle stem cells can regenerate peripheral nerve and spinal cord injuries. In the present study, we regenerated the impinged sciatic nerve by transplanting hair follicle pluripotent stem cells. Human hair follicle stem cells were transplanted around the impinged sciatic nerve of ICR nude (nu/nu) mice. The hair follicle stem cells were transplanted between impinged sciatic nerve fragments of the mouse where they differentiated into glial fibrillary acidic protein-positive Schwann cells and promoted the recovery of pre-existing axons. The regenerated sciatic nerve functionally recovered. These multipotent hair follicle stem cells thereby provide a potential accessible, autologous source of stem cells for regeneration therapy of nerves degenerated by compression between bony or other hard surfaces.
巢蛋白阳性、角蛋白 15（K15）阴性的多能毛囊干细胞位于毛囊隆起上方。我们将这个位置称为毛囊多能干细胞区。我们之前已经证明，移植表达巢蛋白的毛囊干细胞可以再生周围神经和脊髓损伤。在本研究中，我们通过移植毛囊多能干细胞来再生受压的坐骨神经。我们将人毛囊干细胞移植到 ICR 裸鼠（nu/nu）受压坐骨神经周围。毛囊干细胞被移植到受压坐骨神经碎片之间，分化为神经胶质纤维酸性蛋白阳性雪旺细胞，促进了原有轴突的恢复。再生的坐骨神经功能恢复。这些多能毛囊干细胞为因骨骼或其他硬表面压迫而退化的神经的再生治疗提供了一种潜在的、可及的、自体来源的干细胞。
