UPCET et Pharmacologie Clinique, CNRS, Marseille, France.
Mov Disord. 2009 Dec 15;24(16):2316-27. doi: 10.1002/mds.22836.
Impulsivity may be induced by therapeutic interventions (dopamine replacement therapies and sub-thalamic nucleus (STN) stimulation) in patients with Parkinson's disease (PD). The present review has two goals. First, to describe the most frequently encountered facets of cognitive impulsivity and to stress the links between cognitive impulsivity and aspects such as reward-related decision making, risk-taking, and time-processing in healthy population. The most widely used related cognitive impulsivity paradigms are presented. Second, to review the results of studies on cognitive impulsivity in healthy volunteers and in patients with PD, the latter support the applicability and clinical relevance of this construct in PD population. Data show that PD treatments may favor impulsivity via different mechanisms. Suggestions on the roles of dopamine and STN in the pathophysiology of cognitive impulsivity are proposed.
冲动性可能是由帕金森病 (PD) 患者的治疗干预措施（多巴胺替代疗法和丘脑底核 (STN) 刺激）引起的。本综述有两个目的。首先，描述认知冲动性中最常遇到的方面，并强调认知冲动性与健康人群中与奖励相关的决策、冒险和时间处理等方面之间的联系。介绍了最广泛使用的相关认知冲动性范式。其次，回顾了在健康志愿者和 PD 患者中认知冲动性的研究结果，后者支持了这一构念在 PD 人群中的适用性和临床相关性。数据表明，PD 治疗可能通过不同的机制促进冲动性。提出了多巴胺和 STN 在认知冲动性病理生理学中的作用的建议。
