Department of Biochemistry, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK.
Biochem Soc Trans. 2009 Dec;37(Pt 6):1184-8. doi: 10.1042/BST0371184.
The intracellular trafficking of receptors provides a way to control the overall sensitivity of a cell to receptor stimulation. These sorting pathways are also used to shape the balance of signals that are generated in response to receptor activation. The major pro-angiogenic growth factor receptor is VEGFR2 (vascular endothelial growth factor 2). VEGFR2 activates a very similar set of signalling pathways to other RTKs (receptor tyrosine kinases); however, its intracellular trafficking is very different. Furthermore, VEGFR2 can form a complex with a range of different angiogenic regulators that in turn regulate the trafficking of VEGFR2 through the endosomal pathway. This regulated trafficking of VEGFR2 has important consequences for angiogenic signalling and is a clear demonstration of how the endosomal pathway plays a critical role in connecting receptor signalling pathways to cellular events.
细胞内受体运输为控制细胞对受体刺激的整体敏感性提供了一种途径。这些分拣途径还用于塑造响应受体激活而产生的信号的平衡。主要的促血管生成生长因子受体是 VEGFR2（血管内皮生长因子 2）。VEGFR2 激活与其他 RTK（受体酪氨酸激酶）非常相似的信号通路；然而，其细胞内运输却非常不同。此外，VEGFR2 可以与一系列不同的血管生成调节剂形成复合物，这些调节剂反过来又通过内体途径调节 VEGFR2 的运输。VEGFR2 的这种受调控的运输对血管生成信号具有重要意义，清楚地表明了内体途径如何在将受体信号通路与细胞事件联系起来方面发挥关键作用。
