Laboratory for Lymphocyte Differentiation, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa, Japan.
Immunol Rev. 2009 Nov;232(1):300-18. doi: 10.1111/j.1600-065X.2009.00836.x.
The transcription factor nuclear factor-kappaB (NF-kappaB) contributes to many events in the immune system. Characterization of NF-kappaB has facilitated our understanding of immune cell differentiation, survival, proliferation, and effector functions. Intense research continues to elucidate the role of NF-kappaB, which is shared in several receptor signaling pathways, such as Toll-like receptors, the tumor necrosis factor receptor, and antigen receptors. The specificity of cellular responses emanating from stimulation of these receptors is determined by post-translational modification, or 'fine tuning', which regulates spatiotemporal dynamics of downstream signaling. Understanding the fine tuning mechanisms of NF-kappaB activation is crucial for insights into biological regulation and for understanding how cellular signaling pathways are tightly regulated to guide different cell fates. In this review, we focus on recent advances that illuminate the fine tuning mechanisms of NF-kappaB activation by BCR signaling and have increased our comprehension of complex signal systems.
转录因子核因子-κB（NF-κB）参与免疫系统中的许多事件。对 NF-κB 的特征描述有助于我们理解免疫细胞的分化、存活、增殖和效应功能。深入的研究继续阐明 NF-κB 的作用，它在几种受体信号通路中共享，如 Toll 样受体、肿瘤坏死因子受体和抗原受体。这些受体刺激产生的细胞反应的特异性是由翻译后修饰或“微调”决定的，它调节下游信号的时空动态。了解 NF-κB 激活的微调机制对于深入了解生物学调节以及理解细胞信号通路如何受到严格调节以指导不同的细胞命运至关重要。在这篇综述中，我们重点介绍了阐明 BCR 信号转导中 NF-κB 激活的微调机制的最新进展，并提高了我们对复杂信号系统的理解。
