Department of Biochemistry, University of Lausanne, Epalinges, Switzerland.
Immunol Rev. 2009 Nov;232(1):334-47. doi: 10.1111/j.1600-065X.2009.00830.x.
Proteases control many vital aspects of humoral and cellular immune responses, including the maturation of cytokines and the killing of target cells. Recently, it has become evident that triggering of the T-cell receptor controls T-cell proliferation through proteases such as mucosa-associated lymphoid tissue 1 (MALT1) and Caspase-8 that act both as adapters and enzymes. Here, we discuss the role of these and other proteases that are relevant to the control of the T-cell response and represent interesting targets of therapeutic immunomodulation.
蛋白酶控制着体液和细胞免疫反应的许多重要方面，包括细胞因子的成熟和靶细胞的杀伤。最近，人们已经清楚地认识到，T 细胞受体的触发通过作为衔接蛋白和酶的粘膜相关淋巴组织 1（MALT1）和 Caspase-8 等蛋白酶来控制 T 细胞的增殖。在这里，我们讨论了这些蛋白酶以及其他与 T 细胞反应控制相关的蛋白酶的作用，它们是治疗性免疫调节的有趣靶点。
