Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA.
J Neuroimaging. 2011 Apr;21(2):e159-61. doi: 10.1111/j.1552-6569.2009.00442.x.
Studies in patients with extracranial carotid disease have shown that high-resolution magnetic resonance direct thrombus imaging (MRDTI) can reliably identify intraplaque hemorrhage, which may be a better predictor of clinical events than traditional radiographic methods such as percent stenosis. We present the use of high-resolution magnetic resonance imaging for the detection of intraplaque hemorrhage in the intracranial arteries.
High-resolution 3 Tesla MRDTI was performed using T1-weighted scans with an inversion pulse to null the signal from blood. Abnormal intraplaque T1 signal compatible with hemorrhage or blood products was defined as equal to or higher than 150% of T1 signal of adjacent muscle.
The symptomatic middle cerebral artery demonstrated intraplaque signal higher than 150% of the muscle signal in two central slices, consistent with the imaging characteristics of intraplaque hemorrhage demonstrated in extracranial carotid arteries.
High-resolution MRDTI of intracranial atherosclerotic lesions could provide a surrogate marker of plaque activity in vivo and could lead to improvements in risk stratification and treatment of this common disease.
在颅外颈动脉疾病患者中的研究表明，高分辨率磁共振直接血栓成像（MRDTI）可以可靠地识别斑块内出血，其可能比传统的影像学方法（如狭窄百分比）更能预测临床事件。我们提出了使用高分辨率磁共振成像来检测颅内动脉的斑块内出血。
使用带有反转脉冲的 T1 加权扫描进行高分辨率 3 特斯拉 MRDTI，以消除血液的信号。与出血或血液产物一致的斑块内 T1 信号异常定义为等于或高于相邻肌肉 T1 信号的 150%。
症状性大脑中动脉在两个中央层面显示出高于肌肉信号 150%的斑块内信号，与在颅外颈动脉中显示的斑块内出血的影像学特征一致。
颅内动脉粥样硬化病变的高分辨率 MRDTI 可以提供体内斑块活性的替代标志物，并可能导致这种常见疾病的风险分层和治疗的改善。
