Clinic for Preventive Dentistry, Periodontology and Cariology, Center for Dental and Oral Medicine and Maxillofacial Surgery, University of Zurich, Zurich, Switzerland.
J Periodontal Res. 2010 Apr;45(2):153-64. doi: 10.1111/j.1600-0765.2009.01232.x. Epub 2009 Nov 9.
The existing literature is inconsistent regarding whether there is any additional effect of povidone-iodine (PVP-iodine) as an adjunctive to scaling and root planing, and, if there is an effect, what its size is. Therefore, the aim of this study was to assess the additional effect of PVP-iodine as an adjunct to scaling and root planing compared with water, saline or no rinse in the treatment of chronic periodontitis.
An electronic literature search of the databases PubMed, EMBASE and the Cochrane Central Library, and a handsearch, were performed (up to November 2008). Two reviewers independently identified and selected screened abstracts for possible inclusion, and assessed randomized, controlled clinical trials comparing the additional benefit of PVP-iodine with water, saline rinsing or no rinsing in the nonsurgical periodontal therapy of patients with chronic periodontitis. A fixed-effects meta-analysis was conducted in the absence of statistically significant heterogeneity.
A small, but statistically significant additional beneficial effect of the adjunctive use of PVP-iodine with enhanced probing pocket depth reductions of 0.28 mm (95% confidence interval: 0.08 to 0.48, p = 0.007) was found. There was no significant heterogeneity between studies (I(2) = 0%). However, most of the studies included in the meta-analysis were of low quality, and the treatment modalities showed various differences such as the use of PVP-iodine at different concentrations and application modalities. Nevertheless, single-rooted teeth, in particular, showed an additional benefit after scaling and root planing with PVP-iodine, particularly when the treatment was repeated during the healing stage.
The adjunctive use of PVP-iodine during scaling and root planing may increase the clinical pocket depth reduction, although the clinical significance is small to moderate.
现有文献对于聚维酮碘（PVP-碘）作为龈下刮治和根面平整的辅助手段是否有额外效果，以及如果有效果，其效果大小如何，观点并不一致。因此，本研究旨在评估 PVP-碘作为龈下刮治和根面平整辅助手段，与水、盐水或不冲洗相比，在治疗慢性牙周炎方面的额外效果。
对 PubMed、EMBASE 和 Cochrane 中心图书馆的电子文献进行检索，并进行手工检索（截至 2008 年 11 月）。两位评价者独立识别并选择可能纳入的筛选摘要，并评估了比较慢性牙周炎患者非手术牙周治疗中 PVP-碘与水、盐水冲洗或不冲洗相比额外获益的随机对照临床试验。如果没有统计学上的异质性，采用固定效应荟萃分析。
发现 PVP-碘辅助使用具有较小但有统计学意义的额外益处，可使探诊袋深度减少 0.28mm（95%置信区间：0.08 至 0.48，p=0.007）。研究之间没有显著的异质性（I(2)=0%）。然而，荟萃分析中纳入的大多数研究质量较低，且治疗方式存在各种差异，如 PVP-碘的使用浓度和应用方式不同。尽管如此，尤其是在牙周愈合阶段重复治疗时，单根牙在接受 PVP-碘龈下刮治和根面平整后，仍有额外获益。
在龈下刮治和根面平整过程中使用 PVP-碘可能会增加临床袋深度的减少，尽管临床意义较小至中等。
