[1983年至2000年法国甲状腺癌发病率按肿瘤大小划分的地理变异时间趋势]

[Time trends in the geographic variation of thyroid cancer incidence by tumor size from 1983 to 2000 in France].

作者信息

Leux C, Colonna M, Guizard A V, Uhry Z, Velten M, Ganry O, Schvartz C, Grosclaude P, Molinié F

机构信息

Registre des cancers de Loire-Atlantique et de Vendée, plateau des écoles, 50, route de Saint-Sébastien, 44093 Nantes cedex 1, France.

出版信息

Rev Epidemiol Sante Publique. 2009 Dec;57(6):403-10. doi: 10.1016/j.respe.2009.08.008.

DOI:10.1016/j.respe.2009.08.008

PMID:19910147

Abstract

BACKGROUND

The aim of this investigation was to study geographic time trends of thyroid cancer incidence according to tumor size in France, 1983 to 2000.

METHODS

Incidence data were provided from six French registries over the period 1983-2000 covering seven administrative districts. Five tumor size groups were distinguished: < 10mm, 10-20mm, 20-40mm, > 40mm and unknown size. Papillary cancers diagnosed in women were analyzed according to tumor size in each geographic area. World age standardized rates were calculated and annual percent change rates were estimated for each tumor size group in each geographic area. Loglinear Poisson regression models were used to study geographic discrepancies in time trends incidences.

RESULTS

The six French registries included 2222 papillary thyroid cancers in women between 1983 et 2000. Thyroid cancer incidence was increasing in the six geographic areas. Geographical variations in time trends incidence between registries reflected geographical variations in time trends incidence of small sized tumors (less than 10mm).

CONCLUSION

Wide geographic variations in thyroid cancer incidence were noticed for small size tumors, which may be correlated with geographic variations in medical practices.

摘要

背景

本研究旨在探讨1983年至2000年法国甲状腺癌发病率按肿瘤大小划分的地理时间趋势。

方法

发病率数据由法国六个登记处提供，时间跨度为1983 - 2000年，涵盖七个行政区。区分了五个肿瘤大小组：<10mm、10 - 20mm、20 - 40mm、>40mm以及大小未知。根据每个地理区域的肿瘤大小对女性诊断出的乳头状癌进行分析。计算世界年龄标准化率，并估计每个地理区域每个肿瘤大小组的年变化率。使用对数线性泊松回归模型研究发病率时间趋势的地理差异。