Colonna M, Grosclaude P, Remontet L, Schvartz C, Mace-Lesech J, Velten M, Guizard A, Tretarre B, Buemi A V, Arveux P, Esteve J
Registre des Cancers de l'Isère, 21 Chemin des Sources, 38240 Meylan, France.
Eur J Cancer. 2002 Sep;38(13):1762-8. doi: 10.1016/s0959-8049(02)00110-7.
This article analyses time trends and geographical variations of thyroid cancer by histological type. Incidence data were provided by 8 French cancer registries over the period 1978-1997, with 3853 adult cases reported. To assess the effects of age, period, cohort and area on incidence, log-linear Poisson regression models were used. Thyroid cancer increased exponentially from the cohort born in 1925. This increase was essentially due to papillary cancer, which increased by 6.2% per year in men and 8.1% per year in women over the entire period (1978-1997). In women, the recent trends were significantly different between the studied geographical areas. The analysis shows that the increase in thyroid cancer, essentially of the papillary type, is not recent. It may be attributed to a possible screening effect or to an increase in the number of "incidentally" discovered cases linked to the use of modern diagnostic tools.
本文按组织学类型分析了甲状腺癌的时间趋势和地理差异。发病率数据由8个法国癌症登记处提供，涵盖1978 - 1997年期间，共报告了3853例成年病例。为评估年龄、时期、队列和地区对发病率的影响，使用了对数线性泊松回归模型。自1925年出生的队列起，甲状腺癌呈指数增长。这种增长主要归因于乳头状癌，在整个时期（1978 - 1997年）男性每年增长6.2%，女性每年增长8.1%。在女性中，近期趋势在各研究地理区域间存在显著差异。分析表明，甲状腺癌（主要是乳头状癌）的增长并非近期才出现。这可能归因于可能的筛查效应，或与使用现代诊断工具导致的“偶然”发现病例数量增加有关。
