Division of Epilepsy, Mayo Clinic, Rochester, MN 55905, USA.
Epilepsy Behav. 2010 Jan;17(1):87-9. doi: 10.1016/j.yebeh.2009.10.015. Epub 2009 Nov 11.
General anesthesia may be required for particular diagnostic and therapeutic procedures in patients with seizure disorders. There is concern regarding the safety of anesthetic drugs in these individuals because of the reported proconvulsant effect of selected medications. Potentially, general anesthesia may be associated with perioperative seizures or increased adverse effects in people with epilepsy. The rationale for the present study was to evaluate the outcome of general anesthesia in a population-based cohort with seizure disorders undergoing interventions that were unlikely to alter the seizure tendency, for example, magnetic resonance imaging study. Seizures were observed in only 6 of 297 (2%) anesthetic procedures, and intravenous therapy was required in only one patient. None of the patients had any reported adverse effect from general anesthesia. The current findings may be useful in counseling and guiding patients with seizure disorders, their caregivers, and their guardians regarding the risk of general anesthesia.
在癫痫患者中，某些诊断和治疗程序可能需要全身麻醉。由于报告中提到某些药物具有促发癫痫的作用，人们对这些患者使用麻醉药物的安全性表示担忧。全身麻醉可能与围手术期癫痫发作或癫痫患者的不良反应增加有关。本研究的目的是评估在接受不太可能改变癫痫倾向的干预措施（例如磁共振成像研究）的癫痫患者人群中进行全身麻醉的结果。在 297 次麻醉手术中，仅观察到 6 例（2%）癫痫发作，仅 1 例患者需要静脉治疗。没有患者报告全身麻醉有任何不良反应。目前的研究结果可能有助于为癫痫患者及其照顾者和监护人提供有关全身麻醉风险的咨询和指导。
