Environmental and Occupational Medicine, Population Health Section, Division of Applied Health Sciences, University of Aberdeen Medical School, Aberdeen, UK.
Occup Environ Med. 2010 Jun;67(6):401-7. doi: 10.1136/oem.2009.047977. Epub 2009 Nov 11.
Organic solvent exposure may be associated with cognitive impairment in later life although the evidence for this association is inconsistent. This study sought to examine the association between organic solvent exposure and cognitive function in later life.
A prospective longitudinal study set in Aberdeen, Scotland examined 336 men and women born in 1936 who participated in the 1947 Scottish Mental Survey. Cognitive function at age 67 years was measured using the Trail Making Test B (TMT B), the Digit Symbol (DS) test, and the Auditory Verbal Learning Test (AVLT). Occupational hygienists reviewed occupational histories, blind to cognitive function, and estimated lifetime solvent exposures. Multiple regression analyses were employed to explore the association between solvent exposure and cognitive performance after adjustment for confounders.
After adjusting for childhood IQ, smoking, alcohol and sex, the solvent exposed group took on average almost 10 s longer than the unexposed group to complete the TMT B, a highly significant difference. For the DS test, after adjusting for childhood IQ, smoking and gender, the exposed group scored on average two points lower than the unexposed group, which was again highly significant. There was no evidence of an effect for cumulative solvent exposure on the TMT B or DS test. For the AVLT there were no significant differences associated with exposure.
This study of subjects with generally low exposures, found no clear evidence of an association between solvent exposure and cognitive function.
有机溶剂暴露可能与晚年认知障碍有关，尽管这方面的证据并不一致。本研究旨在探讨有机溶剂暴露与晚年认知功能的关系。
一项在苏格兰阿伯丁进行的前瞻性纵向研究，调查了 1936 年出生并参加了 1947 年苏格兰精神调查的 336 名男性和女性。在 67 岁时，使用连线测试 B（TMT B）、数字符号（DS）测试和听觉词语学习测试（AVLT）来测量认知功能。职业卫生学家在不了解认知功能的情况下审查职业史，并估计终生溶剂暴露量。采用多元回归分析方法，在调整了混杂因素后，探讨了溶剂暴露与认知表现之间的关系。
在调整了儿童智商、吸烟、饮酒和性别后，暴露组完成 TMT B 的平均时间比未暴露组长近 10 秒，差异非常显著。对于 DS 测试，在调整了儿童智商、吸烟和性别后，暴露组的平均得分比未暴露组低 2 分，这也是非常显著的。没有证据表明累积溶剂暴露对 TMT B 或 DS 测试有影响。对于 AVLT，与暴露无关的显著差异。
本研究对暴露水平普遍较低的受试者进行研究，没有发现明确的证据表明溶剂暴露与认知功能之间存在关联。
