Cataract, Cornea and External Disease Service, Wilmer Eye Institute, Johns Hopkins Hospital, Baltimore, Maryland, USA.
Curr Opin Ophthalmol. 2010 Jan;21(1):15-9. doi: 10.1097/ICU.0b013e328333e9d6.
Patients with decreased vision due to Fuchs corneal dystrophy and cataract can present with a number of challenges to determine the best surgical option for restoring sight. The ophthalmologist must first distinguish how much of the vision loss is due to the cataract versus the Fuchs corneal dystrophy (FCD) before determining the best surgical course, either cataract surgery alone or cataract surgery combined with full thickness or lamellar keratoplasty. This review will discuss the various techniques and clinical signs to ascertain the source of vision loss and how to use this clinical information to help guide the surgical decision making process in order to optimize the best possible outcome.
Over the last several years, the technique of endothelial keratoplasty has evolved to become an important alternative in the treatment of FCD. Anticipating the correct intraocular lens power for a patient undergoing cataract surgery alone followed by Descemet stripping endothelial keratoplasty (DSEK) or combined cataract surgery with DSEK requires understanding the hyperopic shift that can occur with DSEK and incorporating this correction preoperatively in the intraocular lens power selection.
New developments in the surgical treatment of Fuchs corneal dystrophy have greatly enhanced our ability to restore vision and reduce the dependence on contact lenses in this genetic disease.
目的综述:由于 Fuchs 角膜营养不良和白内障导致视力下降的患者,在确定恢复视力的最佳手术方案时,可能会遇到一些挑战。眼科医生必须首先区分视力下降是由于白内障还是 Fuchs 角膜营养不良(FCD)引起的,然后再确定最佳手术方案,是单独进行白内障手术,还是白内障手术联合全厚或板层角膜移植术。这篇综述将讨论各种技术和临床迹象,以确定视力下降的原因,并利用这些临床信息来帮助指导手术决策过程,以优化最佳结果。
最新发现:在过去几年中,内皮角膜移植术的技术已经发展成为治疗 FCD 的重要替代方法。对于单独进行白内障手术,然后行 Descemet 撕囊内皮角膜移植术(DSEK)或联合白内障手术与 DSEK 的患者,预测正确的人工晶状体度数需要了解 DSEK 可能引起的远视漂移,并在术前根据这一矫正值选择人工晶状体度数。
总结:Fuchs 角膜营养不良的手术治疗新进展极大地提高了我们恢复视力的能力,并减少了这种遗传性疾病对隐形眼镜的依赖。