Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA.
Kidney Int. 2009 Dec;76(11):1125-7. doi: 10.1038/ki.2009.352.
Advanced oxidation protein products (AOPPs), a protein biomarker of increased oxidative stress, are elevated in uremic patients. Zhou et al. demonstrate that chronic administration of AOPPs induces podocyte apoptosis and proteinuria in normal rats via a cascade of signaling events. This study for the first time establishes a causative link between oxidative stress and podocyte depletion and could have broad implications in our understanding of the pathogenic mechanism of proteinuria.
晚期氧化蛋白产物 (AOPPs) 是氧化应激增加的蛋白质生物标志物，在尿毒症患者中升高。Zhou 等人证明，AOPPs 的慢性给药通过一系列信号事件诱导正常大鼠的足细胞凋亡和蛋白尿。这项研究首次在氧化应激与足细胞耗竭之间建立了因果关系，可能对我们理解蛋白尿的发病机制具有广泛的意义。
