Hansen S, Schipper J
Universitätsklinikum Düsseldorf, HNO-Klinik, Düsseldorf.
Laryngorhinootologie. 2009 Nov;88(11):736-40; quiz 741-3. doi: 10.1055/s-0029-1241804. Epub 2009 Nov 12.
Cholesterol granulomas are characterized by an inflammatory reaction with giant cells in response to products of hemoglobin degradation. It can develop in different tissues throughout the body, but as a lesion of the petrous apex it is an own entity. Clinical symptoms may be hearing loss, vertigo, and headache as well as affections of the V-VIII (th) cranial nerves or seizure. Cholesterol granulomas can be identified by typical radiological findings in CT and MRI. Although an unusual entity, cholesterol granulomas are high on the differential of petrous apex lesions and need to be resected via an infralabyrinthine, translabyrinthine or transsphenoidal approach with an establishment of a permanent drainage route in cases of symptomatic clinical presentations.
胆固醇肉芽肿的特征是针对血红蛋白降解产物出现伴有巨细胞的炎症反应。它可在全身不同组织中发生,但作为岩尖病变,它是一种独立的病症。临床症状可能包括听力丧失、眩晕、头痛以及第Ⅴ-Ⅷ对脑神经受累或癫痫发作。胆固醇肉芽肿可通过CT和MRI的典型影像学表现来识别。尽管是一种不常见的病症,但胆固醇肉芽肿在岩尖病变的鉴别诊断中很重要,对于有症状的临床表现,需要通过迷路下、经迷路或经蝶窦入路进行切除,并建立永久性引流途径。