Department of Gynecology and Obstetrics, University Hospital Ulm, Ulm, Germany.
Am J Reprod Immunol. 2010 Jan;63(1):28-37. doi: 10.1111/j.1600-0897.2009.00762.x. Epub 2009 Nov 12.
Inflammatory breast diseases during lactation are major reasons for early weaning.
A prospective cohort study was performed to examine the association between stress and inflammatory breast diseases. Psychometric data, cytokine levels in breast milk and blood samples were analysed postpartum (T1). Psychometric data and course of breast feeding were evaluated twelve weeks later (T2). Patients were divided into case- and control-groups (according to the presence of breast diseases).
Mothers of the case group (n = 23) were significantly older and showed significantly increased stress levels between T1 and T2 compared with the control group (n = 43). Leucocytes in the postpartum blood count were significantly decreased in the case group. There were no significant differences between groups in the concentrations of Th-1- and Th-2-cytokines in breast milk postpartum.
Higher maternal age, postpartum increase in stress perception and low number of leucocytes are associated with a higher incidence of inflammatory breast diseases. Further studies must examine the causality of this effect.
哺乳期炎性乳腺疾病是导致早期断奶的主要原因。
前瞻性队列研究旨在探讨压力与炎性乳腺疾病之间的关系。产后（T1）时分析心理计量数据、母乳和血液样本中的细胞因子水平。12 周后（T2）评估心理计量数据和母乳喂养过程。根据是否存在乳腺疾病，将患者分为病例组（n=23）和对照组（n=43）。
病例组（n=23）的母亲年龄明显较大，与对照组（n=43）相比，T1 至 T2 期间的压力水平明显升高。产后血液计数中的白细胞在病例组中明显减少。产后母乳中 Th1 和 Th2 细胞因子的浓度在组间无显著差异。
较高的母亲年龄、产后压力感知增加和白细胞数量减少与炎性乳腺疾病的发生率较高相关。需要进一步的研究来检验这种影响的因果关系。
