Keogh Institute for Medical Research, Nedlands, Perth, WA, Australia.
J Sex Med. 2010 Jan;7(1 Pt 1):192-202. doi: 10.1111/j.1743-6109.2009.01576.x. Epub 2009 Nov 13.
In spite of the mounting interest in the nexus between erectile dysfunction (ED) and cardiovascular (CV) diseases, there is little published information on the role of ED as a predictor for subsequent CV events.
This study aimed to investigate the role of ED as a predictor for atherosclerotic CV events subsequent to the manifestation of ED. Method. The investigation involved the retrospective study of data on a cohort of men with ED linked to hospital morbidity data and death registrations. By using the linked data, the incidence rates of atherosclerotic CV events subsequent to the manifestation of ED were estimated in men with ED and no atherosclerotic CV disease reported prior to the manifestation of ED. The risk of subsequent atherosclerotic CV events in men with ED was assessed by comparing these incidence rates with those in the general male population.
Standardized incidence rate ratio (SIRR), comparing the incidence of atherosclerotic CV events subsequent to the manifestation of ED in a cohort of 1,660 men with ED to the incidence in the general male population.
On the basis of hospital admissions and death registrations, men with ED had a statistically significantly higher incidence of atherosclerotic CV events (SIRR 2.2; 95% confidence interval 1.9, 2.4). There were significantly increased incidence rate ratios in all age groups younger than 70 years, with a statistically highly significant downward trend with increase of age (P < 0.0001) across these age groups. Younger age at first manifestation of ED, cigarette smoking, presence of comorbidities and socioeconomic disadvantage were all associated with higher hazard ratios for subsequent atherosclerotic CV events.
The findings show that ED is not only significantly associated with but is also strongly predictive of subsequent atherosclerotic CV events. This is even more striking when ED presents at a younger age.
尽管人们对勃起功能障碍（ED）与心血管（CV）疾病之间的关联越来越感兴趣，但关于 ED 作为随后发生 CV 事件的预测因素的信息却很少。
本研究旨在探讨 ED 作为 ED 发生后动脉粥样硬化性 CV 事件预测因子的作用。方法：该研究涉及对一组与医院发病率数据和死亡登记相关的 ED 男性数据的回顾性研究。通过使用链接数据，估计了 ED 发生后 ED 男性中动脉粥样硬化性 CV 事件的发生率，并且在 ED 发生之前没有报告动脉粥样硬化性 CV 疾病。通过将这些发病率与普通男性人群的发病率进行比较，评估 ED 男性发生随后动脉粥样硬化性 CV 事件的风险。
比较 ED 后 1660 名 ED 男性队列中动脉粥样硬化性 CV 事件的发生率与普通男性人群中的发生率，得出标准化发病比（SIRR）。
根据住院和死亡登记，ED 男性发生动脉粥样硬化性 CV 事件的发病率明显更高（SIRR 2.2；95%置信区间 1.9，2.4）。所有年龄组（70 岁以下）的发病率均明显增加，随着年龄的增长，发病率呈统计学显著下降趋势（P <0.0001）。ED 首次发作的年龄越小、吸烟、合并症和社会经济劣势与随后发生动脉粥样硬化性 CV 事件的风险比增加相关。
研究结果表明，ED 不仅与随后发生的动脉粥样硬化性 CV 事件显著相关，而且具有很强的预测性。当 ED 发生在更年轻时，这一点更为明显。
