Petrek J A, Dukoff R, Rogatko A
Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10021.
Cancer. 1991 Feb 15;67(4):869-72. doi: 10.1002/1097-0142(19910215)67:4<869::aid-cncr2820670402>3.0.co;2-q.
The survival of patients with pregnancy-associated (PA) breast cancer is difficult to predict for two reasons: The combination is very rare, and the natural history of breast cancer that is not associated with pregnancy is intricate and varies among individuals. Valid data collection and analysis is problematic given that studies gather patients over many years. The charts of 56 women with Stages I, II, and III breast cancer, who were pregnant or within 1 year postpartum at the time of breast cancer diagnosis between 1960 and 1980, were analyzed. Patients with PA breast cancer were compared to nonpregnant women of comparable ages, who were treated at the same hospital, by the same physicians, and during the same period. Four patients were lost before 5-year follow-up, and one patient before 10-year follow-up. These five patients had distant metastases at the time they were lost to follow-up, and are considered to have died within that time. Across stages, patients with PA breast cancer have survival not significantly different from those patients with non-pregnancy-associated (non-PA) breast cancer.
妊娠相关（PA）乳腺癌患者的生存情况难以预测，原因有二：这种情况非常罕见，且非妊娠相关乳腺癌的自然病程复杂，个体差异较大。鉴于研究是在多年间收集患者数据，有效数据的收集和分析存在问题。对1960年至1980年间乳腺癌诊断时处于妊娠状态或产后1年内的56例I期、II期和III期乳腺癌女性患者的病历进行了分析。将PA乳腺癌患者与年龄相仿、在同一家医院由同一名医生在同一时期治疗的非妊娠女性进行比较。5年随访前有4例患者失访，10年随访前有1例患者失访。这5例患者在失访时已有远处转移，被认为在那段时间内死亡。在各个分期中，PA乳腺癌患者的生存率与非妊娠相关（非PA）乳腺癌患者的生存率无显著差异。
