Department of Molecular & Cell Biology, University of Arizona, Tucson, AZ 85721, USA.
Curr Opin Cell Biol. 2009 Dec;21(6):778-84. doi: 10.1016/j.ceb.2009.10.004. Epub 2009 Nov 11.
Genome rearrangements are important in pathology and evolution. The thesis of this review is that the genome is in peril when replication forks stall, and stalled forks are normally rescued by error-free mechanisms. Failure of error-free mechanisms results in large-scale chromosome changes called gross chromosomal rearrangements, GCRs, by the aficionados. In this review we discuss five error-free mechanisms a replication fork may use to overcome blockage, mechanisms that are still poorly understood. We then speculate on how genome rearrangements may occur when such mechanisms fail. Replication fork recovery failure may be an important feature of the oncogenic process. (Feedback to the authors on topics discussed herein is welcome.).
基因组重排在病理学和进化中很重要。本文的论点是，当复制叉停滞时，基因组就处于危险之中，而停滞的叉通常会被无差错的机制拯救。无差错机制的失败会导致被爱好者称为“巨大染色体重排”的大规模染色体变化。在这篇综述中，我们讨论了复制叉可能用来克服阻塞的五种无差错机制，这些机制仍未被很好地理解。然后，我们推测当这些机制失败时，基因组重排可能是如何发生的。复制叉恢复失败可能是致癌过程的一个重要特征。（欢迎就本文讨论的主题向作者提供反馈）。
