Department of Medical Biochemistry and Biophysics, Umeå University, SE-901 87 Umeå, Sweden.
Trends Endocrinol Metab. 2010 Feb;21(2):96-103. doi: 10.1016/j.tem.2009.10.001. Epub 2009 Nov 11.
To preserve the length of a woman's reproductive life it is essential that the majority of her ovarian primordial follicles are maintained in a quiescent state to provide a reserve for continuous reproductive success. The mechanisms maintaining the dormancy and survival of primordial follicles have been a mystery for decades. In recent years information provided by genetically modified mouse models has revealed a number of molecules whose functions are indispensable for the maintenance of follicular quiescence (including PTEN, Tsc1, Tsc2, Foxo3a, p27) and survival (PI3K signaling). Here we summarize this updated information, which hopefully will lead to a better understanding of the pathophysiology of the human ovary and provide potential therapeutic options for some types of infertility.
为了延长女性的生殖寿命，至关重要的是，女性卵巢中的大多数原始卵泡处于休眠状态，以提供持续生殖成功的储备。几十年来，维持原始卵泡休眠和存活的机制一直是个谜。近年来，基因修饰小鼠模型提供的信息揭示了许多分子，它们的功能对于卵泡静止（包括 PTEN、Tsc1、Tsc2、Foxo3a、p27）和存活（PI3K 信号）是不可或缺的。在这里，我们总结了这些最新信息，希望这将有助于更好地理解人类卵巢的病理生理学，并为某些类型的不孕提供潜在的治疗选择。
