同种异体造血细胞耐药的生物学
The biology of allogeneic hematopoietic cell resistance.
机构信息
Stanford University, Stanford, California 94305, USA.
出版信息
Biol Blood Marrow Transplant. 2010 Jan;16(1 Suppl):S2-7. doi: 10.1016/j.bbmt.2009.11.005. Epub 2009 Nov 12.
Abstract
At the most basic level, success of an allogeneic hematopoietic cell transplantation (HCT) procedure relies upon the engraftment of recipients with donor hematopoietic stem cells (HSCs) that will generate blood formation for the life of that individual. The formula to achieve durable HSC engraftment involves multiple factors including the recipient conditioning regimen, the nature of the genetic disparity between donor and recipient, and the content of the hematopoietic graft. Animal and clinical studies have shown that the biology of host resistance is complex, involving both immune and nonimmune elements. In this article, we review the factors that contribute to host resistance, describe emerging concepts on the basic biology of resistance, and discuss hematopoietic resistance as it relates specifically to patients with severe combined immunodeficiencies (SCID)- disorders that bring unique insights into the dynamics of cell replacement by allogeneic HSCs and progenitor cells.
摘要
在最基本的层面上，异基因造血细胞移植（HCT）程序的成功依赖于供体造血干细胞（HSCs）在受者体内的植入，这些 HSCs 将为该个体的一生提供血液形成。实现持久 HSC 植入的公式涉及多个因素，包括受者的调理方案、供者和受者之间遗传差异的性质，以及造血移植物的内容。动物和临床研究表明，宿主抵抗的生物学是复杂的，涉及免疫和非免疫因素。在本文中，我们综述了宿主抵抗的相关因素，描述了抵抗的基础生物学方面的新观点，并讨论了造血抵抗，特别是与严重联合免疫缺陷（SCID）患者的关系，这为异基因 HSC 和祖细胞的细胞替代动力学提供了独特的见解。
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