Cardiology Unit, Dipartimento di Tecnologie per la Salute, IRCCS Orthopedic Galeazzi Institute, University of Milan, Milan, Italy.
Autoimmun Rev. 2010 Apr;9(6):414-8. doi: 10.1016/j.autrev.2009.11.002. Epub 2009 Nov 12.
Morbidity and mortality rates are higher in rheumatoid arthritis (RA) patients than in the general population. Many studies have shown that coronary artery disease is one of the most common causes of death in RA and seems to occur at a younger age than in the general population. RA per se is as much a cardiovascular (CV) risk factor as diabetes, arterial hypertension and dyslipidemia etc., and so it is necessary to plan a follow-up using the same diagnostic and therapeutic approaches as those commonly used for primary and secondary prevention in non-RA patients at high CV risk. All of the cardiac structures can be affected during the course of RA (valves, the conduction system, the myocardium, endocardium and pericardium, and the coronary arteries), and cardiac complications include a variety of clinical manifestations. As these are all associated with an unfavourable prognosis, it is essential to detect subclinical cardiac involvement in still asymptomatic RA patients in order to assure adequate long-term treatment.
类风湿关节炎(RA)患者的发病率和死亡率高于普通人群。许多研究表明,冠状动脉疾病是 RA 患者最常见的死亡原因之一,且似乎比普通人群更早发生。RA 本身就是心血管(CV)危险因素,与糖尿病、动脉高血压和血脂异常等一样,因此需要采用与非 RA 高 CV 风险患者的一级和二级预防中常用的相同诊断和治疗方法来规划随访。RA 病程中所有的心脏结构都可能受到影响(瓣膜、传导系统、心肌、心内膜和心包以及冠状动脉),心脏并发症包括多种临床表现。由于这些都与预后不良相关,因此,检测仍无症状的 RA 患者的亚临床心脏受累情况对于确保进行充分的长期治疗至关重要。