Pathology Department, National and Kapodistrian University of Athens, Athens, Greece.
Gynecol Oncol. 2010 Mar;116(3):468-72. doi: 10.1016/j.ygyno.2009.10.055. Epub 2009 Nov 14.
To investigate the immunohistochemical profile of cervical mesonephric remnants.
Cases of mesonephric remnants, microglandular hyperplasia, tunnel clusters, tuboendometrioid metaplasia and cervical adenocarcinomas were immunohistochemically stained with Ki-67, CD10, bcl2 and p16. All 26 cases of mesonephric remnants were strongly positive for bcl2 and weakly to moderately positive for p16. CD10 was positive in 19 cases. Seven cases were negative and 19 weakly positive for Ki-67. All 10 cases of tuboendometrioid metaplasia showed high positivity for bcl2. Two cases were negative for p16; seven cases presented low and one case moderate positivity. Five cases were negative for CD10, while in five the staining was low. Six cases of tuboendometrioid metaplasia were negative for Ki-67, while four showed low staining. Tunnel clusters were negative for all antibodies, except one, which showed focal positivity for Ki-67 and p16. All cases of microglandular hyperplasia were negative for bcl2, p16 and CD10 and only 5/12 showed focal positivity for Ki-67. All adenocarcinomas were negative for bcl2 and CD10, and highly positive for p16 and Ki-67.
bcl2 is more constantly and strongly expressed in mesonephric remnants than CD10. p16 is weakly to moderately positive, while Ki-67 is negative to weakly positive.
研究宫颈中肾残留的免疫组织化学特征。
用 Ki-67、CD10、bcl2 和 p16 对中肾残留、微腺体增生、隧道簇、管状子宫内膜样化生和宫颈腺癌病例进行免疫组织化学染色。26 例中肾残留均 bcl2 强阳性，p16 弱阳性至中度阳性。CD10 在 19 例中阳性。7 例为阴性，19 例弱阳性。Ki-67 所有 10 例管状子宫内膜样化生均高度阳性 bcl2。2 例 p16 阴性，7 例低阳性，1 例中度阳性。CD10 5 例阴性，5 例弱阳性。Ki-67 管状子宫内膜样化生 6 例阴性，4 例低阳性。隧道簇除 Ki-67 和 p16 外，所有抗体均阴性，其中 1 例 Ki-67 和 p16 局灶阳性。所有微腺体增生均 bcl2、p16 和 CD10 阴性，仅 5/12 例 Ki-67 局灶阳性。所有腺癌均 bcl2 和 CD10 阴性，p16 和 Ki-67 高度阳性。
bcl2 在中肾残留中的表达比 CD10 更频繁且更强。p16 弱阳性至中度阳性，而 Ki-67 阴性至弱阳性。
