KIF26A是一种非常规驱动蛋白，在肠道神经元发育中调节胶质细胞源性神经营因子（GDNF）-Ret信号通路。
KIF26A is an unconventional kinesin and regulates GDNF-Ret signaling in enteric neuronal development.
作者信息
Zhou Ruyun, Niwa Shinsuke, Homma Noriko, Takei Yosuke, Hirokawa Nobutaka
机构信息
Department of Cell Biology and Anatomy, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan.
出版信息
Cell. 2009 Nov 13;139(4):802-13. doi: 10.1016/j.cell.2009.10.023.
The kinesin superfamily proteins (KIFs) are motor proteins that transport organelles and protein complexes in a microtubule- and ATP-dependent manner. We identified KIF26A as a new member of the murine KIFs. KIF26A is a rather atypical member as it lacks ATPase activity. Mice with a homozygous deletion of Kif26a developed a megacolon with enteric nerve hyperplasia. Kif26a-/- enteric neurons showed hypersensitivity for GDNF-Ret signaling, and we find that KIF26A suppressed GDNF-Ret signaling by direct binding and inhibition of Grb2, an essential component of GDNF/Akt/ERK signaling. We therefore propose that the unconventional kinesin KIF26A plays a key role in enteric nervous system development by repressing a cell growth signaling pathway.
驱动蛋白超家族蛋白（KIFs）是一类运动蛋白，它们以微管和ATP依赖的方式运输细胞器和蛋白质复合物。我们将KIF26A鉴定为小鼠KIFs的一个新成员。KIF26A是一个相当非典型的成员，因为它缺乏ATP酶活性。Kif26a基因纯合缺失的小鼠出现了伴有肠神经增生的巨结肠。Kif26a-/-肠神经元对GDNF-Ret信号表现出超敏反应，并且我们发现KIF26A通过直接结合并抑制Grb2（GDNF/Akt/ERK信号的一个重要组成部分）来抑制GDNF-Ret信号。因此，我们提出非常规驱动蛋白KIF26A通过抑制细胞生长信号通路在肠神经系统发育中起关键作用。
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