Breast Surgery Service, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
Breast. 2009 Oct;18 Suppl 3:S84-6. doi: 10.1016/S0960-9776(09)70279-6.
There is no standard definition of what constitutes an adequate negative margin of resection in invasive cancer or ductal carcinoma in situ (DCIS). The definition of a negative margin used in randomized trials was tumor not touching ink. Tumor touching ink, whether invasive or DCIS, increases the risk of local recurrence (LR). In invasive cancer, convincing evidence that more widely negative margins decrease the risk of LR is lacking, and multiple other biologic and treatment factors influence the risk of LR. In DCIS treated with radiotherapy, evidence that margins wider than 2mm are beneficial is also lacking. Techniques of pathologic processing are a source of variation in margin assessment. The need for margins larger than tumor not touching ink (invasive cancer) and 2mm (DCIS) should be considered in the context of the multiple other factors known to impact upon LR.
在浸润性癌或导管原位癌（DCIS）中，没有明确的标准来定义什么是足够的阴性切缘。在随机试验中使用的阴性切缘定义为肿瘤不接触墨线。肿瘤接触墨线，无论是浸润性还是 DCIS，都会增加局部复发（LR）的风险。在浸润性癌中，缺乏明确证据表明更广泛的阴性切缘可以降低 LR 的风险，并且有多个其他生物学和治疗因素会影响 LR 的风险。在接受放疗的 DCIS 中，也缺乏证据表明 2mm 以上的切缘有益。病理处理技术是导致切缘评估差异的一个因素。在考虑影响 LR 的多个其他因素的情况下，浸润性癌需要大于肿瘤不接触墨线（浸润性癌）和 2mm（DCIS）的切缘，而 DCIS 则需要大于 2mm 的切缘。
